The RNA Methylome Blackboard
نویسندگان
چکیده
منابع مشابه
The human placental methylome.
This review provides an overview of the unique features of DNA methylation in the human placenta. We discuss the importance of understanding placental development, structure, and function in the interpretation of DNA methylation data. Examples are given of how DNA methylation is important in regulating placental-specific gene expression, including monoallelic expression and X-chromosome inactiv...
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Cancer develops not only as a result of genetic mutations and genomic rearrangements, but also as a consequence of numerous epigenetic alterations, including extensive changes in the distribution of DNA methylation throughout the genome. DNA methylation changes contribute directly to cancer by transcriptional silencing of tumorsuppressor genes through promoter CpG island hypermethylation. Broad...
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Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated (>70%). Recently, sequencing of bisulfite-treated DNA (MethylC-seq) has revealed large partially methylated domains (PMDs) in some human cell lines. PMDs cover up to 40% of the genome and are associate...
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Blackboard systems are not new technology. The first blackboard system, the Hearsay-II speech understanding system [1], was developed nearly twenty years ago. While the basic features of Hearsay-II remain in today’s blackboard systems, numerous advances and enhancements have been made as a result of experience gained in using blackboard systems in widely varying application areas. Unlike most A...
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ژورنال
عنوان ژورنال: Circulation
سال: 2019
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.118.038166